Preferred Label : Anti-CSF1R Monoclonal Antibody AMB-05X;
NCIt definition : A human immunoglobulin G2 (IgG2) monoclonal antibody directed against the tyrosine
kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; M-CSFR; c-fms),
also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster
of differentiation 115), with potential antineoplastic, anti-inflammatory, immunomodulating
and anti-fibrotic activities. Upon administration, anti-CSF1R monoclonal antibody
AMB-05X targets and binds to CSF1R expressed on tumor cells, monocytes and macrophages,
and inhibits the binding of the CSF1R ligands and cytokines colony-stimulating factor-1
(CSF-1; CSF1) and interleukin-34 (IL-34) to CSF1R. This prevents CSF1R activation
and CSF1R-mediated signaling in these cells. This blocks tumor cell proliferation
and the production of inflammatory mediators by macrophages and monocytes and reduces
inflammation. By blocking the recruitment to the tumor microenvironment (TME) and
activity of CSF1R-dependent tumor-associated macrophages (TAMs), AMB-05X enhances
T-cell infiltration and antitumor T-cell immune responses, which further inhibits
the proliferation of tumor cells. TAMs play key roles in immune suppression and promoting
inflammation, tumor cell proliferation and survival. In fibrosis, preventing CSF1R-mediated
macrophage differentiation and fibroblast activation may prevent fibrosis. CSF1R,
a cell-surface receptor overexpressed or mutated in certain tumor cell types, plays
major roles in tumor cell proliferation, metastasis, inflammation, and idiopathic
pulmonary fibrosis (IPF). CSF1 is overproduced in certain types of tumors.;
Molecule name : AMB-05X; AMB 05X;
NCI Metathesaurus CUI : CL1648461;
Origin ID : C179168;
UMLS CUI : C5555503;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
