Preferred Label : Axatilimab;
NCIt synonyms : Anti-M-CSFR Monoclonal Antibody SNDX-6352; Axatilimab-csfr;
NCIt definition : A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against colony-stimulating
factor 1 receptor (CSF-1R; CSF1R; macrophage-CSFR; M-CSFR; CD115; c-fms), with potential
antineoplastic activity and anti-inflammatory, immunomodulating and anti-fibrotic
activities. Upon intravenous administration, axatilimab binds to the ligand binding
domain of CSF-1R expressed on monocytes and macrophages, thereby preventing binding
and consequent activation by its natural ligands, interleukin-34 (IL-34) and colony-stimulating
factor 1 (CSF-1). Inhibition of CSF-1R activation and CSF1R-mediated signaling may
reduce the levels of these circulating pro-inflammatory and pro-fibrotic monocytes
and monocyte-derived macrophages. This prevents the secretion of a variety of pro-inflammatory
cytokines by monocytes and macrophages, reduces inflammation, and inhibits the tumor
necrosis factor-beta (TGF-b) secretion by profibrotic (M2) macrophages. This inhibits
the TGF-b-mediated development of fibrosis and may treat chronic graft-versus-host
disease (cGVHD). In addition, by blocking CSF-1R activation and CSF-1R-mediated signaling
in tumor-associated macrophages (TAMs), axatilimab may abrogate the TAMs-mediated
immunosuppression in the tumor microenvironment (TME) and may enhance T-cell infiltration
and antitumor T-cell immune responses. This may inhibit the proliferation of tumor
cells. TAMs play key roles in immune suppression and promoting inflammation, tumor
cell proliferation and survival. CSF-1R is a tyrosine protein kinase that plays an
essential role in the regulation, proliferation, survival and differentiation of tissue
macrophages as well as TAMs.;
UNII : R96Z451BMC;
CAS number : 2155851-88-8;
Drug name : Niktimvo;
Molecule name : UCB6352; SNDX 6352; SNDX-6352; INCA-034176; INCA 034176; INCA 34176; INCA-34176;
NCI Metathesaurus CUI : CL556346;
Codes from synonyms : 142045;
Origin ID : C155813;
UMLS CUI : C5421327;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
