Preferred Label : Axatilimab;
NCIt synonyms : Anti-M-CSFR Monoclonal Antibody SNDX-6352; Axatilimab-csfr;
NCIt definition : A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against colony-stimulating
factor 1 receptor (CSF-1R), with potential antineoplastic activity. Upon intravenous
administration, axatilimab binds to the ligand binding domain of CSF-1R, preventing
binding and consequent activation by its natural ligands, IL-34 and colony-stimulating
factor 1 (CSF-1). Inhibition of CSF-1R activation may disrupt the activity of tumor-associated
macrophages (TAMs), which promote initiation and metastasis of tumor cells, inhibit
T-cell responses, and stimulate tumor angiogenesis and disease progression. CSF-1R,
also known as macrophage colony-stimulating factor receptor (M-CSFR) and cluster of
differentiation 115 (CD115), is a tyrosine-protein kinase that plays an essential
role in the regulation, proliferation, survival and differentiation of tissue macrophages
as well as TAMs.;
UNII : R96Z451BMC;
CAS number : 2155851-88-8;
Drug name : Niktimvo;
Molecule name : UCB6352; SNDX 6352; SNDX-6352;
NCI Metathesaurus CUI : CL556346;
Origin ID : C155813;
UMLS CUI : C5421327;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
