Preferred Label : CSF1R Inhibitor HMPL-653;
NCIt synonyms : Colony-stimulating Factor 1 Receptor Inhibitor HMPL-653; CSF-1R Inhibitor HMPL-653;
NCIt definition : An orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF1R; CSF-1R;
CD115; M-CSFR), with potential immunomodulatory and antineoplastic activities. Upon
oral administration, CSF1R inhibitor HMPL-653 targets and binds to CSF1R, thereby
blocking CSF1R activation and CSF1R-mediated signaling. This inhibits the activities
of tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs),
and prevents immune suppression in the tumor microenvironment (TME). This enhances
antitumor T-cell immune responses and inhibits the proliferation of tumor cells. CSF1R,
also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster
of differentiation 115), is a cell-surface receptor that plays major roles in tumor
cell proliferation and metastasis.;
Molecule name : HMPL-653; HMPL 653;
NCI Metathesaurus CUI : CL1779240;
Origin ID : C187030;
UMLS CUI : C5667090;
Semantic type(s)
- concept_is_in_subset
- has_target
