Transferrin Receptor Protein 1

Preferred Label : Transferrin Receptor Protein 1;

NCIt synonyms : p90; Transferrin Receptor; CD71; Transferrin Receptor 1; TfR; Transferrin Receptor-1; T9; TFR1; TFRC; CD71 Antigen; TR; Trfr;

NCIt definition : Transferrin receptor protein 1 (760 aa, 85 kDa) is encoded by the human TFRC gene. This protein plays a role in the transport of iron into cells.;

NCIt note : Transferrin receptor protein 1 acts as a receptor for the new-world arenaviruses, Guanarito, Junin and Machupo virus. (UniProt); Transferrin receptor protein 1 is cleaved after the arginine residue at position 100 by trypsin to produce the soluble serum form (sTfR).; Transferrin receptor protein 1 is structurally related to the aminopeptidase subfamily M28B but does not appear to have enzymatic activity. (MEROPS);

Details

Origin ID

C38519;

UMLS CUI

C0108801;

Currated CISMeF NLP mapping
- CD71 antigen [MeSH concept]
- CD71 antigen [MeSH Supplementary Concept]
- Transferrin receptor (substance) [SNOMED CT concept]
- receptors, transferrin [MeSH Descriptor]
- receptors, transferrin [MeSH concept]
- transferrin receptor site [SNOMED Notion]
OMIM relation
- Transferrin receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TFRC protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TFRC Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Viral Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Endocytosis Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Phagocytosis Pathway [NCIt concept]
- Vesicle Transport Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Erythropoiesis [NCIt concept]
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Nervous System Development [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Transport Process [NCIt concept]
is_target
- Anti-CD71/vcMMAE Probody-drug Conjugate CX-2029 [NCIt concept]
- Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94 [NCIt concept]

Keyword's position in hierarchy(ies) :

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