Preferred Label : Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94;
NCIt synonyms : TfRscFv/Lip/RB94;
NCIt definition : A systemic gene therapy anti-cancer agent composed of cationic liposomes, which encapsulates
plasmid DNA encoding for the tumor suppressor gene RB94 and is complexed with anti-transferrin
receptor single chain antibody fragment (TfRscFv), with potential antineoplastic activity.
Upon systemic administration of liposome-encapsulated RB94 plasmid DNA gene therapy
agent SGT-94, the TfRscFv portion of this agent selectively targets the tumor cells
expressing transferrin receptors. TfRscFv binding to the transferrin receptor allows
receptor-mediated endocytosis and transfection, followed by the expression of RB94
gene. This induces tumor cell apoptosis through an as of yet unknown pathway. RB94
is a modified, N-terminal truncated form of the full-length protein retinoblastoma
gene RB110, and exerts enhanced antitumor activity. The transferrin receptor (TfR)
functions in cellular iron uptake through its interaction with transferrin, and is
overexpressed in a variety of tumor types.;
Molecule name : SGT-94;
NCI Metathesaurus CUI : CL433963;
Origin ID : C106271;
UMLS CUI : C3827075;
Semantic type(s)
- concept_is_in_subset
- has_target
