" /> C-C Chemokine Receptor Type 5 - CISMeF





Preferred Label : C-C Chemokine Receptor Type 5;

NCIt synonyms : CCR5 Protein; C-C CKR-5; CKR5; CCR-5; Chemokine (C-C Motif) Receptor 5; HIV-1 Fusion Co-Receptor; CHEMR13; Chemokine (C-C) Receptor 5; CMKBR5; CC-CKR-5; CCR5; CCCKR5; CKR-5; CD195 Antigen; C-C Motif Chemokine Receptor-5; CC Chemokine Receptor 5; HIV-1 Fusion Coreceptor; Chemokine Receptor CCR5; C-C Motif Chemokine Receptor 5;

NCIt definition : C-C chemokine receptor type 5 (352 aa, 41 kDa) is encoded by the human CCR5 gene. This protein is involved in the modulation of inflammatory responses and cellular signaling.;

NCIt note : Chemokine (C-C Motif) Receptor 5, encoded by the CCR5 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed by T cells and macrophages, and is an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene is associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene is also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. (From LocusLink); C-C chemokine receptor type 5 acts as a coreceptor (with T-cell surface glycoprotein CD4 as the primary receptor) for HIV.;

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15/05/2024


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