Preferred Label : CCR2/CCR5 Antagonist BMS-813160;
NCIt synonyms : (S)-1-[(1S,2R,4R)-4-isopropyl(methyl)amino)-2-propylcyclohexyl]-3-(6(trifluoromethyl)quinazolin-4-ylamino)pyrrolidin-2-one;
NCIt related terms : BMS-813160;
NCIt definition : An antagonist of both human C-C chemokine receptor types 2 (CCR2; CD192) and 5 (CCR5;
CD195), with potential immunomodulating and antineoplastic activities. Upon administration,
CCR2/CCR5 antagonist BMS-813160 specifically binds and prevents the activation of
both CCR2 and CCR5. This inhibits the activation of CCR2/CCR5-mediated signal transduction
pathways and may inhibit inflammatory processes, angiogenesis, tumor cell migration,
tumor cell proliferation and invasion. The G-protein coupled chemokine receptors CCR2
and CCR5 are expressed on the surface of monocytes and macrophages, and stimulate
their migration and infiltration; they play key roles in inflammation and autoimmune
disease. CCR2 and CCR5 are overexpressed in certain cancer cell types, and are also
involved in angiogenesis, and in tumor cell migration, proliferation and metastasis.;
UNII : 83U7957287;
CAS number : 1286279-29-5;
Molecule name : BMS-813160;
Origin ID : C139550;
UMLS CUI : C3490973;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
