C-C Chemokine Receptor Type 2

Preferred Label : C-C Chemokine Receptor Type 2;

NCIt synonyms : MCP-1 Receptor; CC-CKR-2; Monocyte Chemotactic Protein 1 Receptor; MCP-1-R; Monocyte Chemoattractant Protein 1 Receptor; CD192 Antigen; CCR2; CD192; CCR-2; C-C CKR-2; Antigen CD192;

NCIt definition : C-C chemokine receptor type 2 (374 aa, 42 kDa) is encoded by the human CCR2 gene. This protein plays a role in both cytokine binding and receptor signaling.;

Details

Origin ID

C101579;

UMLS CUI

C3538748;

Automatic exact mappings (from CISMeF team)
- Chemokine, CC motif, receptor 2 [OMIM gene]
- receptors, ccr2 [MeSH Descriptor]
OMIM relation
- Chemokine, CC motif, receptor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CCR2 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Defense Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- CCR2 Antagonist CCX872-B [NCIt concept]
- CCR2 Antagonist PF-04136309 [NCIt concept]
- CCR2/CCR5 Antagonist BMS-813160 [NCIt concept]
- Copper Cu 64-DOTA-ECL1i [NCIt concept]
- Plozalizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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