Preferred Label : CCR2-targeting Chimera STX-0712;
NCIt synonyms : CCR2 targeting Cytotoxicity Targeting Chimera STX-0712; CCR2-CyTAC STX-0712;
NCIt definition : A C-C chemokine receptor type 2 (CCR2)-targeting chimera, composed of a bifunctional
small molecule with a CCR2-binding moiety and a linker that conjugates to an antibody-dependent
cellular cytotoxicity (ADCC)-enhanced antibody, with potential antineoplastic activity.
Upon administration of CCR2-targeting chimera STX-0712, the CCR2-binding moiety targets
and binds to CCR2 expressed on malignant monocytes, and the antibody moiety induces
ADCC against the CCR2-expressing malignant monocytes, thereby killing malignant monocytes.
The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages,
and stimulates their migration and infiltration; it plays a key role in inflammation.
CCR2 is overexpressed in certain cancers, including chronic myelomonocytic leukemia
(CMML), and it is involved in angiogenesis, tumor cell migration and proliferation.;
Molecule name : STX-0712; STX 0712;
Origin ID : C217534;
concept_is_in_subset
- has_target
