Preferred Label : Copper Cu 64-DOTA-ECL1i;
NCIt synonyms : 64Cu-DOTA-ECL1i; 64Cu-d(LGTFLKC);
NCIt definition : A radiotracer composed of ECL1i (extracellular loop 1 inverso; d(LGTFLKC)), an allosteric
peptidic modulator of CC chemokine receptor type 2 (CCR2), conjugated with 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic
acid (DOTA) and labeled with the radionuclide copper Cu 64, with potential imaging
activity upon positron emission tomography (PET). Upon administration, the ECL1i moiety
targets and allosterically binds to CCR2 expressing tumor cells. Upon PET imaging,
the copper Cu 64 moiety can be visualized, thereby allowing the quantification of
CCR2-expressing cells. CCR2, a G-protein coupled receptor expressed on the surface
of monocytes and macrophages, stimulates the migration and infiltration of these cell
types, and plays a significant role in angiogenesis, inflammation, tumor cell migration,
and proliferation. Quantification of CCR2 may help predict chemotherapy resistance
and identify early metastatic disease in certain cancers.;
NCI Metathesaurus CUI : CL950986;
Origin ID : C158983;
UMLS CUI : C5204132;
Semantic type(s)
- concept_is_in_subset
- has_target
