Preferred Label : Plozalizumab;
NCIt synonyms : Immunoglobulin G1, Anti-(Human CC Chemokine Receptor CCR2) (Human-mus musculus Monoclonal
1d9 Heavy Chain), Disulfide with Human-mus musculus Monoclonal 1d9 kappa-chain, Dimer;
NCIt related terms : anti-CCR2 monoclonal antibody MLN1202; MLN1202;
NCIt definition : A humanized monoclonal antibody directed against the human chemokine receptor 2 (CCR2),
with potential antiangiogenic, immunomodulating, antimetastatic, and antineoplastic
activities. Plozalizumab binds to CCR2 and prevents binding of the endothelium-derived
CLL2 (monocyte chemoattractant protein-1 or MCP1) to its receptor CCR2, which may
result in inhibition of CCR2 activation and so inhibition of angiogenesis, tumor cell
migration, and tumor cell proliferation. In addition, this agent may reduce levels
of C-reactive protein (CRP). The G-protein coupled receptor CCR2 is expressed on the
surface of monocytes and macrophages, stimulates the migration and infiltration of
these cell types, and plays an important role in inflammation, angiogenesis, and tumor
cell migration and proliferation.;
Alternative definition : NCI-GLOSS: A substance being studied as a treatment for atherosclerosis (a build-up
of fat in the arteries). It is also being studied in the treatment of cancers that
spread to the bone. Anti-CCR2 monoclonal antibody MLN1202 binds to a protein called
CCR2, which is found on the surface of certain bone cells, white blood cells, and
cancer cells. Anti-CCR2 monoclonal antibody MLN1202 blocks the action of a substance
that is involved in keeping healthy bone mass. It may help keep the cancer cells from
spreading to and growing in the bone. It is a type of monoclonal antibody.;
UNII : 4XG66BMN0D;
CAS number : 1610761-46-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1610761-46-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : MLN1202;
Codes from synonyms : CDR0000663296; CDR0000663297;
Origin ID : C88308;
UMLS CUI : C4287798;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
