Preferred Label : CCR2 Antagonist CCX872-B;
NCIt definition : An orally available human C-C chemokine receptor type 2 (CCR2) antagonist, with potential
immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist
CCX872-B specifically binds to CCR2 and prevents the binding its cognate endothelium-derived
chemokine ligand CCL2 (monocyte chemoattractant protein-1 or MCP1). This may result
in the inhibition of both CCR2 activation and CCR2-mediated signal transduction, which
may inhibit inflammatory processes, angiogenesis, tumor cell migration, and tumor
cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface
of monocytes and macrophages, and stimulates their migration and infiltration; it
plays a key role in inflammation. CCR2 is overexpressed in certain cancer cell types,
where it is involved in angiogenesis, tumor cell migration and proliferation.;
Molecule name : CCX872-B;
Origin ID : C120302;
UMLS CUI : C3896888;
Semantic type(s)
- concept_is_in_subset
- has_target
