CXCR2 wt Allele

Preferred Label : CXCR2 wt Allele;

NCIt synonyms : Interleukin 8 Receptor, Beta Gene; Interleukin 8 Receptor, Type 2 Gene; CMKAR2; CDw128b; IL8R2; Chemokine, CXC Motif, Receptor 2 Gene; CD182; Chemokine (C-X-C Motif) Receptor 2 wt Allele; IL8RB; IL8RB wt Allele;

NCIt definition : Human CXCR2 wild-type allele is located within 2q35 and is approximately 11 kb in length. This allele, which encodes C-X-C chemokine receptor type 2 protein, is involved in the mediation of neutrophil migration to sites of inflammation, cellular growth, and angiogenic effects in intestinal microvascular endothelial cells. Allelic variants of the gene are associated with serum-dependent melanoma cell growth.;

NCIt note : Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration.;

GenBank Accession Number : NM_001557;

Details

Origin ID

C51372;

UMLS CUI

C1704986;

OMIM relation
- Chemokine, cxc motif, receptor 2 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 2: 218816252-218827481 [NCIt concept]
gene_in_chromosomal_location
- 2q35 [NCIt concept]
gene_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
gene_plays_role_in_process
- Chemotactic Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Neutrophil Activation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients