Beta-1 Adrenergic Receptor

Preferred Label : Beta-1 Adrenergic Receptor;

NCIt synonyms : Beta 1 Receptor; Beta-1 Adrenoceptor; ADRB1; Beta-1 Adrenoreceptor; Beta 1 Adrenergic Receptor; Beta-1-Adrenergic Receptor;

NCIt definition : Beta-1 adrenergic receptor (477 aa, 51 kDa) is encoded by the human ADRB1 gene. This protein plays a role in catecholamine-dependent G protein-coupled receptor signaling.;

NCIt note : Encoded by human ADRB1 Gene (GPCR1 Family), 477-aa 51-kDa conserved Beta-1-Adrenergic Receptor is an integral membrane protein receptor for catecholamine epinephrine and norepinephrine neurotransmitters that activates adenylate cyclase through G protein action. ADRB1 phosphorylation by beta-adrenergic receptor kinase mediates receptor desensitization. Agonist and antagonist drugs selective for beta-1 receptors have important applications in clinical medicine.;

Details

Origin ID

C40096;

UMLS CUI

C2932458;

Currated CISMeF NLP mapping
- Beta-1 adrenergic receptor (substance) [SNOMED CT concept]
- Beta-1-adrenergic receptor [OMIM Phenotype]
- receptors, adrenergic, beta-1 [MeSH Descriptor]
- receptors, adrenergic, beta-1 [MeSH concept]
OMIM relation
- Beta-1-adrenergic receptor [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ADRB1 protein, human [MeSH Supplementary Concept]
- ADRB1 protein, human [MeSH concept]
- Beta-1 adrenergic receptor (substance) [SNOMED CT concept]
- beta-1 adrenergic receptor site [SNOMED Notion]
- receptors, adrenergic, beta-1 [MeSH concept]
- receptors, adrenergic, beta-1 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ADRB1 Gene [NCIt concept]
- Beta Adrenergic Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Adrenergic Receptor [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Dilated Cardiomyopathy Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Gap Junction Assembly Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Atenolol [NCIt concept]
- Metoprolol [NCIt concept]

Keyword's position in hierarchy(ies) :

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