C-C Chemokine Receptor Type 6

Preferred Label : C-C Chemokine Receptor Type 6;

NCIt synonyms : G Protein-Coupled Receptor 29; GPR29; CCR6 Protein; LARC Receptor; Chemokine (C-C) Receptor 6; GPR-CY4; STRL22; CMKBR6; CKRL3; GPRCY4; Seven-Transmembrane Receptor, Lymphocyte, 22; CCR6; DRY-6; CKR6; CC-CKR-6; CKR-L3; Chemokine Receptor-Like 3; CCR-6; DRY6; DCR2; C-C CKR-6; BN-1; Chemokine (C-C Motif) Receptor 6; CD196 Antigen; C-C Motif Chemokine Receptor-6;

NCIt definition : C-C chemokine receptor type 6 (374 aa, 42 kDa) is encoded by the human CCR6 gene. This protein plays a role in chemokine signaling.;

NCIt note : Chemokine (C-C Motif) Receptor 6, encoded by the CCR6 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. The CCR6 gene is preferentially expressed by immature dendritic cells and memory T cells. This receptor mediates intracellular calcium flux and binds specifically to the CC chemokine macrophage inflammatory protein 3 alpha (MIP-3 alpha). It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (From LocusLink);

Details

Origin ID

C25778;

UMLS CUI

C1308121;

OMIM relation
- Chemokine, CC motif, receptor 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CCR6 protein, human [MeSH Supplementary Concept]
- CCR6 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CCR6 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Dendritic Cell [NCIt concept]
- T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Calcium Signaling [NCIt concept]
- Cell Defense Process [NCIt concept]
- Cell Motility [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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