C-X-C Chemokine Receptor Type 2

Preferred Label : C-X-C Chemokine Receptor Type 2;

NCIt synonyms : Chemokine (C-X-C) Receptor 2; IL8 Receptor Type 2; Interleukin 8 Receptor Type 2; GRO/MGSA Receptor; IL8RB; Interleukin 8 Receptor Type B; High Affinity Interleukin 8 Receptor Type B; IL-8 Receptor Type 2; CD182; Interleukin 8 Receptor Beta; Interleukin-8 Receptor Type 2; CD182 Antigen; CDw128b; CXC-R2; Interleukin-8 Receptor Beta; Interleukin-8 Receptor Type B; CXCR-2; High Affinity Interleukin-8 Receptor B; IL-8R B;

NCIt definition : C-X-C chemokine receptor type 2 (360 aa, 41 kDa) is encoded by the human CXCR2 gene. This protein plays a role in both chemokine binding and neutrophil activation.;

NCIt note : The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (OMIM);

Details

Origin ID

C26289;

UMLS CUI

C4082290;

OMIM relation
- Chemokine, cxc motif, receptor 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CXCR2 Gene [NCIt concept]
- Chemokine Receptor Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
- Interleukin-8 Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Chemokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Endocytosis Pathway [NCIt concept]
- Epithelial Cell Signaling Pathway in Helicobacter pylori Infection [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Immunoregulation [NCIt concept]
- Inflammatory Response [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Neutrophil Activation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- CXC Chemokine Receptor 2 Antagonist AZD5069 [NCIt concept]
- CXCR1/2 Inhibitor RP72 [NCIt concept]
- CXCR2 Agonist MGTA-145 [NCIt concept]
- CXCR2 Antagonist QBM076 [NCIt concept]
- Ladarixin [NCIt concept]
- Ladarixin Sodium [NCIt concept]
- Navarixin [NCIt concept]
- Reparixin [NCIt concept]

Keyword's position in hierarchy(ies) :

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