Preferred Label : CXCR2 Antagonist QBM076;
NCIt definition : An orally available small molecule antagonist of the G protein-coupled receptor, C-X-C
motif chemokine receptor 2 (CXCR2), with potential immunomodulating and antineoplastic
activities. Upon administration, QBM076 binds to and inhibits the activation of CXCR2,
resulting in reduced neutrophil recruitment, myeloid-derived suppressor cell (MDSC)
accumulation, and may potentially slow tumorigenesis and metastatic processes. CXCR2
is upregulated in a variety of cancer types, predominately in neutrophils/MDSCs rather
than tumor cells, and is thought to contribute to tumor cell proliferation, invasion,
and metastasis.;
Molecule name : QBM-076; QBM 076;
NCI Metathesaurus CUI : CL554404;
Origin ID : C153151;
UMLS CUI : C4727060;
Semantic type(s)
- concept_is_in_subset
- has_target
