" /> Reparixin - CISMeF





Preferred Label : Reparixin;

NCIt synonyms : Repertaxin; 2-(4-Isobutylphenyl)propionylmethanesulfonamide; Benzeneacetamide, Alpha-methyl-4-(2-methylpropyl)-N- (methylsulfonyl)- (alphaR)-;

NCIt definition : An orally available inhibitor of CXC chemokine receptor types 1 (CXCR1) and 2 (CXCR2), with potential antineoplastic activity. Upon administration, reparixin allosterically binds to CXCR1 and prevents CXCR1 activation by its ligand interleukin 8 (IL-8 or CXCL8). This may cause cancer stem cell (CSC) apoptosis and may inhibit tumor cell progression and metastasis. CXCR1, overexpressed on CSCs, plays a key role in CSC survival and the ability of CSC to self-renew; it is also linked to tumor resistance to chemotherapy. Inhibition of the IL-8/CXCR1 interaction also potentiates the cytotoxic effect of chemotherapeutic agents. In addition, reparixin inhibits CXCR2 activation and may reduce both neutrophil recruitment and vascular permeability during inflammation or injury.;

UNII : U604E1NB3K;

InChIKey : KQDRVXQXKZXMHP-LLVKDONJSA-N;

CAS number : 266359-83-5;

Molecule name : DF 1681Y;

Chemical formula : C14H21NO3S;

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31/05/2025


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