CXCR2 Agonist MGTA-145

Preferred Label : CXCR2 Agonist MGTA-145;

NCIt synonyms : GRO-beta; GROb;

NCIt definition : An agonist of CXC chemokine receptor type 2 (CXCR2), with potential hematopoietic stem cell (HSC) mobilization activity. Upon administration, CXCR2 agonist MGTA-145 binds to and activates CXCR2. This releases matrix metalloproteinase-9 (MMP-9), resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. The HSCs can be collected for autologous and allogeneic stem cell transplantation.;

Molecule name : MGTA-145; MGTA 145;

NCI Metathesaurus CUI : CL1642607;

Details

Origin ID

C176851;

UMLS CUI

C5447471;

See also inter- (CISMeF)
- Chemokine, cxc motif, ligand 2 [OMIM gene]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- C-X-C Chemokine Receptor Type 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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