Preferred Label : Navarixin;
NCIt synonyms : 2-Hydroxy-N,N-dimethyl-3-((2-((1R)-1-(5-methylfuran-2-yl)propyl)amine)-3,4- dioxocyclobut-1-enyl)amino)benzamide
Monohydrate;
NCIt definition : An orally available small molecule antagonist of the C-X-C motif chemokine receptor
1 (CXCR1; interleukin-8 receptor alpha; IL8RA) and 2 (CXCR2; interleukin-8 receptor
beta; IL8RB), with potential immunomodulating and antineoplastic activities. Upon
administration, navarixin binds to and inhibits the activation of CXCR 1 and 2. This
inhibits CXCR1/2-mediated signaling, reduces both recruitment and migration of immunosuppressive
myeloid-derived suppressor cells (MDSCs) and neutrophils in the tumor microenvironment
(TME), inhibits inflammatory processes and abrogates the immunosuppressive nature
of the TME. This allows effector cells, such as natural killer (NK) cells and cytotoxic
T-lymphocytes (CTLs), to kill and eliminate cancer cells. This inhibits tumor cell
migration, metastasis, angiogenesis and tumor cell proliferation. CXCR 1 and 2, G
protein-coupled receptor proteins located on myeloid cells and certain tumor cells,
play key roles in the immunosuppressive nature of the TME, tumor metastasis, therapy-resistance,
myeloid cell suppression, and inflammation.;
UNII : 7V3BY6G538;
InChIKey : OVPWPDFETBKAQQ-UNTBIKODSA-N;
CAS number : 862464-58-2;
Molecule name : SCH 527123; MK-7123; PS291822;
NCI Metathesaurus CUI : CL935858;
Origin ID : C156730;
UMLS CUI : C4519192;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
