Preferred Label : Phospholipase C-Epsilon Signaling Pathway;
NCIt related terms : Phospholipase C-epsilon pathway;
Alternative definition : BIOCARTA: Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium
signaling. Receptors coupling to Gs stimulate AC, resulting in elevated cAMP levels
and activation of Epac1. Epac1 then catalyses GTP-loading on Rap2B, which leads to
PLC-e activation. The proposed pathway may involve additional signaling components
to attain PLC stimulation. The action of cAMP seems to be independent of PKA; instead,
the cAMP-activated Rap-GEF Epac seems to serve as a cAMP effector, inducing GTP loading
and, hence, activation of Rap2B, which then leads to specific activation of PLC-e,
which has been shown to interact with Rap GTPases. It is an attractive hypothesis,
therefore, that the Rap-dependent PLC and calcium signaling pathway reported here
is not restricted to Gs-and AC-coupled receptors, such as the b2-AR and the prostanoid
receptor, but could be used by other receptors as well. (This definition may be outdated
- see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_plcePathway;
Origin ID : C39193;
UMLS CUI : C1519053;
Semantic type(s)
has_gene_product_element
pathway_has_gene_element