NCIt definition : Expressed in effector tissues innervated by postganglionic sympathetic adrenergic
fibers, Beta Adrenergic Receptor Genes encode Beta Adrenergic Receptors, one of two
major classes of adrenergic receptors (alpha and beta) based on their reactions to
norepinephrine and epinephrine, on cellular effects of receptor activation, and on
relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic
receptors respond to blocking agents such as propranolol and to activating agents
such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac
rate and force of contraction; beta-2 type receptor activation promotes bronchial
and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs
protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic
AMP. (NCI);
Semantic type(s)