Beta Adrenergic Receptor

Preferred Label : Beta Adrenergic Receptor;

NCIt synonyms : ADRB;

NCIt definition : Expressed by Beta Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI);

Details

Origin ID

C17062;

UMLS CUI

C0034785;

Currated CISMeF NLP mapping
- Beta adrenergic receptor [FMA entity]
- Beta-adrenergic receptor (substance) [SNOMED CT concept]
- beta-adrenergic receptor site [SNOMED Notion]
- receptors, adrenergic, beta [MeSH Descriptor]
- receptors, adrenergic, beta [MeSH concept]
False automatic mappings
- Beta-2-adrenergic receptor [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Beta adrenergic receptor [FMA entity]
- Beta-adrenergic receptor (substance) [SNOMED CT concept]
- beta-adrenergic receptor site [SNOMED Notion]
- receptors, adrenergic, beta [MeSH concept]
- receptors, adrenergic, beta [MeSH Descriptor]
gene_encodes_gene_product
- Beta Adrenergic Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Adrenergic Receptor [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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