Alpha-1A Adrenergic Receptor

Preferred Label : Alpha-1A Adrenergic Receptor;

NCIt synonyms : ADRA1C; ADRA1L1; Alpha 1A-Adrenoceptor; ADRA1A; Alpha-1C Adrenergic Receptor; Adrenergic, Alpha-1A-, Receptor; Adrenergic, Alpha-1C-, Receptor; Alpha-Adrenergic Receptor 1c; Alpha-1C-Adrenergic Receptor; Alpha-1A Adrenoreceptor; Alpha-1A Adrenoceptor;

NCIt definition : Alpha-1A adrenergic receptor (466 aa, 51 kDa) is encoded by the human ADRA1A gene. This protein is involved in smooth muscle contraction, cell proliferation, apoptosis and signal transduction.;

NCIt note : Alpha-1A-adrenergic receptor, encoded by the ADRA1A gene, regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(Q) and G(11) proteins. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. Its carboxyl-terminal SER or THR residues may be phosphorylated. (From LocusLink, Swiss_Prot and NCI);

Details

Origin ID

C21285;

UMLS CUI

C2932393;

Currated CISMeF NLP mapping
- receptor, adrenergic, alpha-1A [MeSH concept]
OMIM relation
- Alpha-1a-adrenergic receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ADRA1A protein, human [MeSH concept]
- ADRA1A protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- ADRA1A Gene [NCIt concept]
- Alpha Adrenergic Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Brain [NCIt concept]
- Heart [NCIt concept]
- Liver [NCIt concept]
- Prostate Gland [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Adrenergic Receptor [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Calcium-Mediated Signaling Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Muscle Contraction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients