NCIt definition : Expressed in effector tissues innervated by postganglionic sympathetic adrenergic
fibers, Alpha Adrenergic Receptor Genes encode Alpha Adrenergic Receptors, one of
two major classes of adrenergic receptors (alpha and beta) based on their reactions
to norepinephrine and epinephrine, on cellular effects of receptor activation, and
on relative affinities and reactions to synthetic blocking or stimulating agents.
Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and
phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic
Receptor stimulation results in decreased intracellular cyclic AMP.;
Semantic type(s)