Alpha-2A Adrenergic Receptor

Preferred Label : Alpha-2A Adrenergic Receptor;

NCIt synonyms : ADRA2A; Alpha-2A-Adrenergic Receptor; Alpha-2AAR; Alpha-2A Adrenoreceptor; Alpha-2AAR Subtype C10; Alpha-2A Adrenoceptor; Alpha-2 Adrenergic Receptor Subtype C10;

NCIt definition : Alpha-2A adrenergic receptor (465 aa, 51 kD) is a cell motility protein that is encoded by the human ADRA2A gene. This protein plays a role in actin cytoskeletal organization, cell motility, regulation of cell proliferation and signal transduction.;

NCIt note : Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. These receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. Alpha-2A-adrenergic receptor is encoded by the ADRA2A gene. Both the alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity.;

Details

Origin ID

C21287;

UMLS CUI

C1741862;

Automatic exact mappings (from CISMeF team)
- Alpha-2a-adrenergic receptor [OMIM gene]
- adrenoceptor alpha 2A [HGNC gene]
- receptors, adrenergic, alpha-2 [MeSH Descriptor]
Currated CISMeF NLP mapping
- receptor, adrenergic, alpha-2A [MeSH concept]
OMIM relation
- Alpha-2a-adrenergic receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ADRA2A protein, human [MeSH Supplementary Concept]
- ADRA2A protein, human [MeSH concept]
- receptor, adrenergic, alpha-2A [MeSH concept]
gene_encodes_gene_product
- ADRA2A Gene [NCIt concept]
- Alpha Adrenergic Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Adrenergic Receptor [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Motility [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
- Regulation of Cell Size [NCIt concept]
- Signal Transduction [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]

Keyword's position in hierarchy(ies) :

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