Alpha Adrenergic Receptor

Preferred Label : Alpha Adrenergic Receptor;

NCIt synonyms : ADRA;

NCIt definition : Expressed by Alpha Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP.;

Details

Origin ID

C20932;

UMLS CUI

C0034784;

Automatic exact mappings (from CISMeF team)
- alpha-adrenergic receptor site [SNOMED Notion]
Currated CISMeF NLP mapping
- Alpha adrenergic receptor [FMA entity]
- receptors, adrenergic, alpha [MeSH Descriptor]
- receptors, adrenergic, alpha [MeSH concept]
False automatic mappings
- Alpha-adrenergic receptor (substance) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- Alpha adrenergic receptor [FMA entity]
- Alpha-adrenergic receptor (substance) [SNOMED CT concept]
- alpha-adrenergic receptor site [SNOMED Notion]
- receptors, adrenergic, alpha [MeSH concept]
- receptors, adrenergic, alpha [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Alpha Adrenergic Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Etilefrine Hydrochloride [NCIt concept]
- Etilefrine Pivalate [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Adrenergic Receptor [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Clonidine-containing Mucoadhesive Buccal Tablet [NCIt concept]

Keyword's position in hierarchy(ies) :

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