Alpha-2B Adrenergic Receptor

Preferred Label : Alpha-2B Adrenergic Receptor;

NCIt synonyms : ADRA2B; Alpha-2B Adrenoceptor; Alpha 2B Adrenergic Receptor; Alpha-2BAR; Alpha-2B Adrenoreceptor; Alpha-2B-Adrenergic Receptor;

NCIt definition : Alpha-2B adrenergic receptor (450 aa, 50 kDa) is encoded by the human ADRA2B gene. This protein plays a role in catacholamine-dependent signaling.;

NCIt note : Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The alpha2B subtype, encoded by the ADRA2B gene is associated with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. This polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences.;

Details

Origin ID

C21289;

UMLS CUI

C2932442;

Currated CISMeF NLP mapping
- receptor, adrenergic, alpha-2B [MeSH concept]
OMIM relation
- Alpha-2b-adrenergic receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ADRA2B protein, human [MeSH concept]
- ADRA2B protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- ADRA2B Gene [NCIt concept]
- Alpha Adrenergic Receptor Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Adrenergic Receptor [NCIt concept]
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Obesity [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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