cGMP-Dependent Protein Kinase 1

Preferred Label : cGMP-Dependent Protein Kinase 1;

NCIt synonyms : cGMP-Dependent Protein Kinase I; cGKI-Alpha; cGK 1; EC 2.7.11.12; cGKI-BETA; cGKI; cGK1;

NCIt definition : cGMP-dependent protein kinase 1 (671 aa, 76 kDa) is encoded by the human PRKG1 gene. This protein is involved in nitric oxide/cyclic GMP-dependent signal transduction.;

NCIt note : cGMP-dependent protein kinase 1 may be involved in protecting the heart from hypertrophic heart disease. (Nature. 2015; 519:472-476.);

Details

Origin ID

C125497;

UMLS CUI

C3489929;

Automatic exact mappings (from CISMeF team)
- Protein kinase, cgmp-dependent, regulatory, type I [OMIM gene]
- cGKIbeta [MeSH concept]
- cyclic GMP-Dependent protein kinase type I [MeSH Descriptor]
- protein kinase cGMP-dependent 1 [ORDO Gene]
- protein kinase cGMP-dependent 1 [HGNC gene]
- protein kinase modulator [MeSH Supplementary Concept]
OMIM relation
- Protein kinase, cgmp-dependent, regulatory, type I [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PRKG1 protein, human [MeSH Supplementary Concept]
- PRKG1 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PRKG1 Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Gap Junction Assembly Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Olfactory Transduction Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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