PRKG2 wt Allele

Preferred Label : PRKG2 wt Allele;

NCIt synonyms : PRKGR2; Protein Kinase, cGMP-Dependent, Type II wt Allele; cGK, Type II Gene; cGKII; cGK2;

NCIt definition : Human PRKG2 wild-type allele is located in the vicinity of 4q13.1-q21.1 and is approximately 116 kb in length. This allele, which encodes cGMP-dependent protein kinase 2 protein, is involved in cGMP-dependent signaling which regulates cellular processes such as cytoskeletal organization and cell motility. The PRKG2 gene is associated with long-term depression.;

NCIt note : The PRKG2 gene undergoes alternative splicing to produce two RNA variants (6 kb and 4.4 kb) and two corresponding isoforms of cGMP-dependent protein kinase 2 protein.;

GenBank Accession Number : NM_006259;

Details

Origin ID

C51173;

UMLS CUI

C1706142;

OMIM relation
- Protein kinase, cgmp-dependent, type II [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 4q13.1-q21.1 [NCIt concept]
gene_is_element_in_pathway
- Gap Junction Assembly Pathway [NCIt concept]
- Ion Channels in Vascular Endothelium Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Olfactory Transduction Pathway [NCIt concept]
- Salivary Secretion Pathway [NCIt concept]
gene_plays_role_in_process
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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