Tilarginine - CISMeF

Preferred Label : Tilarginine;

NCIt synonyms : N-Methylarginine; omega-N-Monomethylarginine; NMA; Targinine; N5-(Methylamidino)-L-ornithine; MMA; L-NMMA; Monomethylarginine;

NCIt related terms : NG-monomethyl-L-arginine;

NCIt definition : A pan-nitric oxide synthase (NOS) inhibitor, with potential immunomodulating and antineoplastic activities. Upon administration, tilarginine binds to and inhibits NOS, a free radical signaling molecule that promotes angiogenesis, metastasis, and immunosuppression in the tumor microenvironment (TME). Reduction in NOS activity may abrogate the immunosuppressive TME, enhance tumor antigen-specific immune response and inhibit tumor cell proliferation.;

Alternative definition : NCI-GLOSS: An amino acid derivative used to counteract high blood pressure caused by interleukin-2.;

UNII : 27JT06E6GR;

InChIKey : NTNWOCRCBQPEKQ-YFKPBYRVSA-N;

CAS number : 17035-90-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 17035-90-4 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C7H16N4O2;

NSC code : 683245;

ChEBI ID : CHEBI:28229;

Codes from synonyms : CDR0000045437;

Details

Origin ID

C1178;

UMLS CUI

C0069477;

Currated CISMeF NLP mapping
- omega-N-Methylarginine [MeSH concept]
- omega-N-Methylarginine [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- omega-N-Methylarginine [MeSH concept]
- omega-N-Methylarginine [MeSH Descriptor]
chemical_or_drug_affects_gene_product
- Nitric Oxide Synthase, Brain [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of Angiogenesis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Tilarginine Acetate [NCIt concept]
is_component_of_chemotherapy_regimen
- Interleukin-2/NG-Monomethyl-L-Arginine [NCIt concept]
is_free_acid_or_base_form_of
- Tilarginine Acetate [NCIt concept]

Keyword's position in hierarchy(ies) :

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