Nicastrin - CISMeF

Preferred Label : Nicastrin;

NCIt synonyms : NCSTN;

NCIt definition : Nicastrin (709 aa, 78 kDa) is encoded by the human NCSTN gene. This protein is involved in the regulation of intramembrane cleavage catalyzed by the gamma-secretase complex.;

Details

Origin ID

C162434;

UMLS CUI

C5202778;

Automatic exact mappings (from CISMeF team)
- nicastrin [ORDO Gene]
OMIM relation
- Nicastrin [OMIM gene]
See also inter- (CISMeF)
- Nicastrin [OMIM gene]
- nicastrin [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- NCSTN Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- NCSTN NP_056146.1:p.A572G [NCIt concept]
- NCSTN Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Gamma Secretase [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Regulated Intramembrane Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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