Regulated Intramembrane Proteolysis

Preferred Label : Regulated Intramembrane Proteolysis;

NCIt synonyms : Intramembrane Proteolysis; RIP;

NCIt definition : A process that involves the proteolysis of an integral membrane protein at a site that is within its transmembrane domain. This cleavage causes the release of cytosolic fragments that can enter the nucleus and regulate transcription.;

NCIt note : Regulated intramembrane proteolysis of a transmembrane protein usually follows the proteolytic shedding of the extracellular domain. Regulated intramembrane proteolysis is involved in many biological processes including embryonic development, cholesterol signaling and Alzheimer disease.;

Details

Origin ID

C95245;

UMLS CUI

C2987018;

Semantic type(s)
- Phenomenon or Process [UMLS semantic type]
biological_process_involves_gene_product
- Gamma-Secretase Subunit PEN-2 [NCIt concept]
- Membrane-Bound Transcription Factor Site-2 Protease [NCIt concept]
- Nicastrin [NCIt concept]
- SH3 Domain-Containing Protein 19 [NCIt concept]
biological_process_is_part_of_process
- Biochemical Process [NCIt concept]
- Post-Translational Regulation [NCIt concept]
process_involves_gene
- MBTPS2 Gene [NCIt concept]
- MBTPS2 wt Allele [NCIt concept]
- NCSTN Gene [NCIt concept]
- NCSTN wt Allele [NCIt concept]
- PSENEN Gene [NCIt concept]
- PSENEN wt Allele [NCIt concept]
- SH3D19 Gene [NCIt concept]
- SH3D19 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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