Membrane-Bound Transcription Factor Site-2 Protease

Preferred Label : Membrane-Bound Transcription Factor Site-2 Protease;

NCIt synonyms : MBTPS2; EC 3.4.24.85; Sterol Regulatory Element-Binding Proteins Intramembrane Protease; Endopeptidase S2P; SREBPs Intramembrane Protease; Site-2 Protease;

NCIt definition : Membrane-bound transcription factor site-2 protease (519 aa, 57 kDa) is encoded by the human MBTPS2 gene. This protein plays a role in the intramembrane proteolysis of sterol regulatory element-binding proteins (SREBPs).;

Details

Origin ID

C203776;

UMLS CUI

C1438353;

OMIM relation
- Membrane-bound transcription factor protease, site 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- MBTPS2 protein, human [MeSH Supplementary Concept]
- MBTPS2 protein, human [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- MBTPS2 Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Membrane of the Golgi Apparatus [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Regulated Intramembrane Proteolysis [NCIt concept]
- Unfolded Protein Response [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients