Gamma-Secretase Subunit APH-1B

Preferred Label : Gamma-Secretase Subunit APH-1B;

NCIt synonyms : Aph-1beta; APH-1b; Presenilin-Stabilization Factor-Like; APH1B;

NCIt definition : Gamma-secretase subunit APH-1B (257 aa, 28 kDa) is encoded by the human APH1B gene. This protein is involved in gamma-secretase complex assembly.;

NCIt note : There are at least 2 isoforms of gamma-secretase subunit APH-1B that result from alternative splicing.;

Détails

Origin ID

C212955;

OMIM relation
- Aph1 homolog b, gamma-secretase subunit [OMIM gene]
gene_encodes_gene_product
- APH1B Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Gamma Secretase [NCIt concept]
gene_product_plays_role_in_biological_process
- Intercellular Communication Process [NCIt concept]
- Regulated Intramembrane Proteolysis [NCIt concept]

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