Gamma Secretase

Preferred Label : Gamma Secretase;

NCIt synonyms : Gamma-Secretase;

NCIt definition : A protein complex that plays a role in the intramembrane cleavage of integral proteins such as Notch receptors and amyloid beta A4 protein.;

NCIt note : The components required for the enzymatic activity of gamma secretase are a homodimer of presenilin (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. The proteolytic activity appears to be mediated by presenilin, while the other proteins are required for both stabilization of the active form of presenilin and localization of the complex.;

Details

Origin ID

C95114;

UMLS CUI

C0379528;

Automatic exact mappings (from CISMeF team)
- amyloid precursor protein secretases [MeSH Descriptor]
Currated CISMeF NLP mapping
- gamma-Secretase [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- gamma-Secretase [MeSH concept]
gene_product_is_element_in_pathway
- Amyloid Beta-Peptide Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Gamma-Secretase Mediated ErbB4 Signaling Pathway [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Notch and Wnt Signaling Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- Segmentation Clock Pathway [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Proteolysis [NCIt concept]
- Signal Transduction [NCIt concept]
has_gene_product_element
- Gamma-Secretase Subunit PEN-2 [NCIt concept]
- Nicastrin [NCIt concept]
- Presenilin-1 [NCIt concept]
- Presenilin-2 [NCIt concept]
is_target
- Crenigacestat [NCIt concept]
- GS/pan-Notch Inhibitor AL102 [NCIt concept]
- Gamma-Secretase Inhibitor LY3039478 [NCIt concept]
- Gamma-Secretase Inhibitor RO4929097 [NCIt concept]
- Nirogacestat [NCIt concept]
- Nirogacestat Hydrobromide [NCIt concept]
- Notch Signaling Pathway Inhibitor MK0752 [NCIt concept]
- Osugacestat [NCIt concept]

Keyword's position in hierarchy(ies) :

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