NCIt definition : A selective gamma secretase (GS) inhibitor with antitumor activity. Upon administration,
nirogacestat targets and binds to GS, thereby blocking the proteolytic activation
of Notch receptors. This inhibits the Notch signaling pathway and results in the induction
of apoptosis in tumor cells that overexpress Notch. The integral membrane protein
GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins,
such as Notch receptors, at residues within their transmembrane domains. Overexpression
of the Notch signaling pathway has been correlated with increased tumor cell growth
and survival.;