amyloid precursor protein secretases

Preferred Label : amyloid precursor protein secretases;

MeSH definition : Endopeptidases that are specific for AMYLOID PROTEIN PRECURSOR. Three secretase subtypes referred to as alpha, beta, and gamma have been identified based upon the region of amyloid protein precursor they cleave.;

MeSH synonym : app secretase; Secretases; Secretase; amyloid precursor protein secretase; secretase, app;

MeSH hyponym : beta-Secretase; gamma-Secretase; alpha-Secretase; beta Secretase; gamma Secretase; alpha Secretase;

MeSH Related Number : beta-Secretase; gamma-Secretase; alpha-Secretase; EC 3.4.-;

Registry Number MeSH : EC 3.4.-;

Related CAS MeSH : EC 3.4.- (beta-Secretase); EC 3.4.- (gamma-Secretase); EC 3.4.- (alpha-Secretase);

Wikipedia link : https://en.wikipedia.org/wiki/Alpha-secretase;

Is substance : O;

Details

Origin ID

D053829;

UMLS CUI

C0171484;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Cathepsin B [NCIt concept]
Indexing information
- (1-(4-methyl-1-(6-(trifluoromethyl)-3-pyridinyl)pentyl)-2-(4-(trifluoromethyl)phenyl)-4-piperidinyl)acetic acid [MeSH Supplementary Concept]
- 1-(1-(4-fluorophenyl)ethyl)-3-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)methylene)-2-piperidinone [MeSH Supplementary Concept]
- 1-(3',4'-dichloro-2-fluoro(1,1'-biphenyl)-4-yl)cyclopropanecarboxylic acid [MeSH Supplementary Concept]
- 2',3',4',5,5',6,7,8,9,10-decahydro-2-(5-(4-fluorophenyl)-1-methylpyrazol-3-yl)-5'-(2,2,2-trifluoroethyl)spiro(6,9-methanobenzocycloocten-11,3'-(1,2,5)thiadiazole) 1',1'-dioxide [MeSH Supplementary Concept]
- 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide [MeSH Supplementary Concept]
- 2-(((3,5-difluorophenyl)acetyl)amino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)propanamide [MeSH Supplementary Concept]
- 2-(2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-(3-methyl-4-oxo-4,5-dihydro-3H-benzo(d)(1,2)diazepin-5-yl)propanamide [MeSH Supplementary Concept]
- 2-(2-(3,5-difluorophenyl)-acetylamino)-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo(e)(1,4)diazepin-3-yl)propionamide [MeSH Supplementary Concept]
- 2-(3,5-bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid [MeSH Supplementary Concept]
- 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-3-cyclobutylpropanoic acid [MeSH Supplementary Concept]
- 2-(N-((3-(1,2,4-oxadiazol-3-yl)bicyclo(1.1.1)pentan-1-yl)methyl)-4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide [MeSH Supplementary Concept]
- 3-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid [MeSH Supplementary Concept]
- 4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo(4,3-c)quinoline [MeSH Supplementary Concept]
- 6-hydroxy-4-oxo-N-(10-((1,2,3,4-tetrahydroacridin-9-yl)amino)decyl)-4H-chromene-2-carboxamide [MeSH Supplementary Concept]
- BMS 708163 [MeSH Supplementary Concept]
- GRL 7234 [MeSH Supplementary Concept]
- GRL 8234 [MeSH Supplementary Concept]
- MRK 003 [MeSH Supplementary Concept]
- N-(1-(3,5-difluorobenzyl)-2-hydroxy-3-(3-iodobenzylamino)propyl)-5-methyl-N',N'-dipropylisophthalamide [MeSH Supplementary Concept]
- N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester [MeSH Supplementary Concept]
- N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide [MeSH Supplementary Concept]
- SCH 1500022 [MeSH Supplementary Concept]
- SCH 900229 [MeSH Supplementary Concept]
- begacestat [MeSH Supplementary Concept]
- benzyloxycarbonyl-isoleucyl-leucinal [MeSH Supplementary Concept]
- benzyloxycarbonyl-leucyl-leucyl-norleucinal [MeSH Supplementary Concept]
- curcumin-isoleucine [MeSH Supplementary Concept]
- curcumin-phenylalanine [MeSH Supplementary Concept]
- curcumin-valine [MeSH Supplementary Concept]
- dibenzazepine [MeSH Supplementary Concept]
- nirogacestat [MeSH Supplementary Concept]
Record concept(s)
- alpha-Secretase [MeSH concept]
- amyloid precursor protein secretases [MeSH concept]
- beta-Secretase [MeSH concept]
- gamma-Secretase [MeSH concept]
Related MeSH Supplementary Concept(s)
- ADAM10 protein, human [MeSH Supplementary Concept]
- Adam10 protein, mouse [MeSH Supplementary Concept]
- BACE1 protein, human [MeSH Supplementary Concept]
- BACE1 protein, zebrafish [MeSH Supplementary Concept]
- BACE2 protein, human [MeSH Supplementary Concept]
- BACE2 protein, zebrafish [MeSH Supplementary Concept]
- Bace1 protein, mouse [MeSH Supplementary Concept]
- Bace1 protein, rat [MeSH Supplementary Concept]
- Bace2 protein, mouse [MeSH Supplementary Concept]
- Bace2 protein, rat [MeSH Supplementary Concept]
- PSENEN protein, human [MeSH Supplementary Concept]
- nicastrin protein [MeSH Supplementary Concept]
- presenilin enhancer 2, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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