Notch Signaling Pathway Inhibitor MK0752

Preferred Label : Notch Signaling Pathway Inhibitor MK0752;

NCIt related terms : MK0752; MK-0752;

NCIt definition : A synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks signals between growing cells and may kill cancer cells. It is a type of signal transduction inhibitor.;

UNII : 9JD9B4S53T;

InChIKey : XCGJIFAKUZNNOR-QCKZDCLWSA-N;

CAS number : 471905-41-6;

Molecule name : MK-0752;

Codes from synonyms : CDR0000615393;

Details

Origin ID

C49175;

UMLS CUI

C1708824;

Automatic exact mappings (from CISMeF team)
- 3-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid [MeSH Supplementary Concept]
- MK 0752 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MK 0752 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Gamma Secretase [NCIt concept]

Keyword's position in hierarchy(ies) :

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