Presenilin-2 - CISMeF

Preferred Label : Presenilin-2;

NCIt synonyms : EC 3.4.23.-; AD5; AD3LP; PS-2; STM-2; E5-1; Presenilin 2; PSEN2;

NCIt definition : Presenilin-2 (448 aa, 50 kDa) is encoded by the human PSEN2 gene. This protein is involved in proteolytic processing.;

NCIt note : Presenilin-2 is autocatalytically processed, which generates an amino terminal fragment (NTF) and a carboxyl terminal fragment (CTF). The NTF and CTF are maintained as a disulfide-linked heterodimer. This cleavage is required for gamma secretase activity.;

Details

Origin ID

C95122;

UMLS CUI

C1311406;

Automatic exact mappings (from CISMeF team)
- AD 5 [MeSH Supplementary Concept]
- ALP56 enzyme [MeSH Supplementary Concept]
- AT1G11910 protein, Arabidopsis [MeSH Supplementary Concept]
- AXP protein, yarrowia lipolytica [MeSH Supplementary Concept]
- Acasp1 protein, ancylostoma caninum [MeSH Supplementary Concept]
- Alzheimer disease 5 [OMIM Phenotype]
- Alzheimer's disease 5 [DO Concept]
- Aspergillus oryzae carboxyl proteinase [MeSH Supplementary Concept]
- BAR1 protein, S cerevisiae [MeSH Supplementary Concept]
- Bace protein, Drosophila [MeSH Supplementary Concept]
- CDR1 protein, arabidopsis [MeSH Supplementary Concept]
- DASP1 protein, drosophila [MeSH Supplementary Concept]
- EapB protein, cryphonectria parasitica [MeSH Supplementary Concept]
- EapC protein, cryphonectria parasitica [MeSH Supplementary Concept]
- FIV protease [MeSH Supplementary Concept]
- Gvp36 protein, S cerevisiae [MeSH Supplementary Concept]
- HIV protease [MeSH Descriptor]
- HTLV-1 protease [MeSH Supplementary Concept]
- MKC7 protein, S cerevisiae [MeSH Supplementary Concept]
- Mason-Pfizer monkey virus protease [MeSH Supplementary Concept]
- NAPSA protein, human [MeSH Supplementary Concept]
- Napsa protein, rat [MeSH Supplementary Concept]
- PCS1 proteinase, arabidopsis [MeSH Supplementary Concept]
- PEP4 protein, S cerevisiae [MeSH Supplementary Concept]
- PepE protein, aspergillus niger [MeSH Supplementary Concept]
- Presenilin 2 [OMIM gene]
- SAP1 protein, candida albicans [MeSH Supplementary Concept]
- SAP2 protein, candida [MeSH Supplementary Concept]
- SAP3 protein, candida albicans [MeSH Supplementary Concept]
- SAP4 protein, candida albicans [MeSH Supplementary Concept]
- SAP5 protein, candida albicans [MeSH Supplementary Concept]
- SIV(mac) proteinase [MeSH Supplementary Concept]
- SPP protein, arabidopsis [MeSH Supplementary Concept]
- SPPL2a protein, human [MeSH Supplementary Concept]
- SPPL2a protein, mouse [MeSH Supplementary Concept]
- SPPL2b protein, human [MeSH Supplementary Concept]
- SPPL2b protein, mouse [MeSH Supplementary Concept]
- Sap8 protein, candida albicans [MeSH Supplementary Concept]
- Sap9 protein, candida albicans [MeSH Supplementary Concept]
- SpoIIGA protein, bacillus subtilis [MeSH Supplementary Concept]
- SppL protein, drosophila [MeSH Supplementary Concept]
- YPS3 protein, S cerevisiae [MeSH Supplementary Concept]
- allergen bla g 2 [MeSH Supplementary Concept]
- aspartic acid endopeptidases [MeSH Descriptor]
- aspartic proteinase A [MeSH Supplementary Concept]
- aspartic proteinase, irpex lacteus [MeSH Supplementary Concept]
- aspartic proteinase-I [MeSH Supplementary Concept]
- aspartic proteinases, cynara cardunculus [MeSH Supplementary Concept]
- aspartyl protease, sclerotinia sclerotiorum [MeSH Supplementary Concept]
- aspergillus acid proteinase [MeSH Supplementary Concept]
- aspergillus niger AP 114 protease [MeSH Supplementary Concept]
- boophilus yolk pro-cathepsin [MeSH Supplementary Concept]
- byssochlamyopeptidase A [MeSH Supplementary Concept]
- copia protein, drosophila [MeSH Supplementary Concept]
- cyprosin [MeSH Supplementary Concept]
- eimepsin [MeSH Supplementary Concept]
- endothia aspartic proteinase [MeSH Supplementary Concept]
- extracellular carboxyl proteinase, candida pulcherrima [MeSH Supplementary Concept]
- kdap protein, mouse [MeSH Supplementary Concept]
- kumamolysin [MeSH Supplementary Concept]
- nucellin [MeSH Supplementary Concept]
- oryzasin [MeSH Supplementary Concept]
- p16 protease, human immunodeficiency virus 1 [MeSH Supplementary Concept]
- p16 protease, human immunodeficiency virus 2 [MeSH Supplementary Concept]
- plasmapepsin IV [MeSH Supplementary Concept]
- podosporapepsin [MeSH Supplementary Concept]
- pregnancy-associated glycoprotein 1 [MeSH Supplementary Concept]
- pregnancy-associated glycoprotein 2 [MeSH Supplementary Concept]
- preprorennin [MeSH Supplementary Concept]
- presenilin 2 [ORDO Gene]
- presenilin 2 [HGNC gene]
- presenilinase, human [MeSH Supplementary Concept]
- procardosin A [MeSH Supplementary Concept]
- procathepsin D [MeSH Supplementary Concept]
- procathepsin E [MeSH Supplementary Concept]
- pronapsin [MeSH Supplementary Concept]
- proplasmepsin II [MeSH Supplementary Concept]
- prorennin [MeSH Supplementary Concept]
- protease p15 [MeSH Supplementary Concept]
- protease, moloney murine leukemia virus [MeSH Supplementary Concept]
- proteinase, foamy virus [MeSH Supplementary Concept]
- rennin-like enzyme (Aspergillus ochraceus) [MeSH Supplementary Concept]
- rhizopuspepsinogen [MeSH Supplementary Concept]
- rhodopsin cleaving enzyme [MeSH Supplementary Concept]
- rous sarcoma virus protease [MeSH Supplementary Concept]
- scytalidium lignicolum acid proteases [MeSH Supplementary Concept]
- signal peptide peptidase [MeSH Supplementary Concept]
- signal peptide peptidase like 3, human [MeSH Supplementary Concept]
- skin aspartic protease, human [MeSH Supplementary Concept]
- sppl2 protein, zebrafish [MeSH Supplementary Concept]
- syncephapepsin [MeSH Supplementary Concept]
- ulysses retrotransposon aspartic proteinase, drosophila [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Presenilin-2 [MeSH Descriptor]
- Presenilin-2 [MeSH concept]
OMIM relation
- Presenilin 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PSEN2 protein, human [MeSH Supplementary Concept]
- PSEN2 protein, human [MeSH concept]
- Presenilin-2 [MeSH concept]
- Presenilin-2 [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- PSEN1 Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_chemical_classification
- Aspartyl Peptidase [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- HIV-1 Nef: Negative Effector Pathway for Fas and TNF-Alpha [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Gamma Secretase [NCIt concept]
gene_product_malfunction_associated_with_disease
- Alzheimer's Disease [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
- Proteolysis [NCIt concept]
- Proteolytic Processing [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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