Gamma-Secretase Subunit PEN-2

Preferred Label : Gamma-Secretase Subunit PEN-2;

NCIt synonyms : PSENEN; Presenilin Enhancer Protein 2; Hematopoietic Stem/Progenitor Cells Protein MDS033;

NCIt definition : Gamma-secretase subunit PEN-2 (101 aa, 12 kDa) is encoded by the human PSENEN gene. This protein plays a role in Notch protein cleavage and signal transduction.;

Details

Origin ID

C104809;

UMLS CUI

C3537462;

OMIM relation
- Presenilin enhancer, gamma-secretase subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PSENEN Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Nerve Growth Factor Receptor Signaling Pathway [NCIt concept]
- Notch Signaling Pathway [NCIt concept]
- Presenilin Action in Notch and Wnt Signaling Pathways [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
gene_product_is_physical_part_of
- Gamma Secretase [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Regulated Intramembrane Proteolysis [NCIt concept]
- Regulation of Proteolysis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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