Gamma-Secretase Inhibitor RO4929097

Preferred Label : Gamma-Secretase Inhibitor RO4929097;

NCIt synonyms : R04929097;

NCIt related terms : RO4929097; RG-4733;

NCIt definition : An orally bioavailable, small-molecule gamma secretase (GS) inhibitor with potential antitumor activity. Gamma secretase inhibitor RO4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It blocks certain enzymes that are needed for cell growth. This may slow the growth of cancer cells. It may also decrease the growth of new blood vessels that tumors need to grow. It is a type of gamma-secretase inhibitor and a type of Notch signaling inhibitor.;

UNII : KK8645V7LE;

CAS number : 847925-91-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 847925-91-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RO4929097;

Codes from synonyms : CDR0000666221;

Details

Origin ID

C88333;

UMLS CUI

C2742210;

Automatic exact mappings (from CISMeF team)
- 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide [MeSH Supplementary Concept]
- R04929097 [MeSH concept]
Currated CISMeF NLP mapping
- RO 4929097 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- RO 4929097 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Gamma Secretase [NCIt concept]

Keyword's position in hierarchy(ies) :

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