Insulin-Degrading Enzyme

Preferred Label : Insulin-Degrading Enzyme;

NCIt synonyms : EC 3.4.24.56; Abeta-Degrading Protease; Insulysin; Insulinase; Insulin Protease; IDE;

NCIt definition : Insulin-degrading enzyme (1019 aa, 118 kDa) is encoded by the human IDE gene. This protein is involved in the metabolism of bioactive peptides.;

NCIt note : Substrates for insulin-degrading enzyme include beta amyloid, amylin-containing amyloid, insulin, glucagon, bradykinin and kallidin. (UniProt);

NCI Metathesaurus CUI : CL1647980;

Details

Origin ID

C112878;

UMLS CUI

C5441715;

Automatic exact mappings (from CISMeF team)
- Insulin-degrading enzyme [OMIM gene]
- Insulysin (substance) [SNOMED CT concept]
- insulin degrading enzyme [HGNC gene]
- insulysin [MeSH Descriptor]
- insulysin [MeSH concept]
- nurses [MeSH Descriptor]
OMIM relation
- Insulin-degrading enzyme [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- IDE protein, human [MeSH Supplementary Concept]
- Insulysin (substance) [SNOMED CT concept]
- insulysin [MeSH Descriptor]
- insulysin [MeSH concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- IDE Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Peptide Metabolism [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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