Preferred Label : Neprilysin;
NCIt synonyms : Common ALL Antigen; Common Acute Lymphoblastic Leukemia Antigen; NEP; MME; cALLa; Enkephalinase; Neutral Endopeptidase; Skin Fibroblast Elastase; CD10 Antigen; Atriopeptidase; EC 3.4.24.11; Antigen CD10; SFE; Membrane Metalloendopeptidase;
NCIt related terms : CD10;
NCIt definition : Neprilysin (750 aa, 86 kDa) is encoded by the human MME gene. This protein is involved
in the metabolism of biologically active peptides.;
NCIt note : Membrane Metalloendopeptidase is a zinc-binding type II transmembrane glycoprotein
that preferentially cleaves Gly-Phe bonds of peptides at the N side of hydrophobic
residues and inactivates several peptide hormones, including insulin, glucagon, enkephalins,
substance P, neurotensin, oxytocin, and bradykinin, as well as casein, hemoglobin,
and other proteins and polypeptides. An important cell surface marker of human acute
lymphocytic leukemia, MME is present on pre-B leukemic cells, which represent 85%
of cases of ALL.;
Origin ID : C16836;
UMLS CUI : C3887624;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_biomarker_type
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
