neprilysin - CISMeF

Preferred Label : neprilysin;

MeSH definition : Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.;

MeSH synonym : metalloendopeptidase, thermolysin-like; kidney brush border neutral proteinase; carboxypeptidase, enkephalin dipeptidyl; endopeptidase 24.11, neutral; calla antigen; neutral endopeptidase; membrane metallo endopeptidase; membrane metallo-endopeptidase; neutral endopeptidase 24.11; antigens, cd10; enkephalinase 24.11; enzyme, ygg-forming; ygg-forming enzyme; enkephalinase; enkephalinase-24.11; kidney-brush-border neutral proteinase; neutral proteinase, kidney-brush-border; metallo-endopeptidase, membrane; endopeptidase, neutral; thermolysin-like metalloendopeptidase; thermolysin like metalloendopeptidase; ygg forming enzyme; common acute lymphoblastic leukemia antigens; antigens, leukemia, common acute lymphoblastic; atriopeptidase; cd10 antigen; antigen, cd10; cd10 antigens; endopeptidase-24.11; endopeptidase 24.11; enkephalin dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase, enkephalin;

Registry Number MeSH : EC 3.4.24.11;

Wikipedia link : https://en.wikipedia.org/wiki/Neprilysin;

Is substance : O;

UNII : EC 3.4.24.11;

Details

Origin ID

D015260;

UMLS CUI

C0025250;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Neprilysin [NCIt concept]
Indexing information
- 2-((1-(((1-(carboxymethyl)-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl)amino)carbonyl)cyclopentyl)methyl)-4-((3-(methylamino)propyl)(methyl)amino)-4-oxobutanoic acid [MeSH Supplementary Concept]
- 2-(1-((2-ethyl-1,3,4-thiadiazol-5-yl)aminocarbonyl)cyclopentyl)pentanoic acid [MeSH Supplementary Concept]
- 2-(2-(5-bromoindan-1-yl)-3-mercaptopropionylamino)-3-(1H-pyrrolo(2,3-b)pyridin-3-yl)propionic acid [MeSH Supplementary Concept]
- 3-(1-((2-ethyl-1,3,4-thiazol-5-yl)aminocarbonyl)cyclopent-1-yl)-2-propylpropionic acid [MeSH Supplementary Concept]
- 3-(2-benzyl-3-(propionylthio)propionyl)amino-5-methybenzoic acid [MeSH Supplementary Concept]
- 3-(N-hydroxycarboxamido-2-benzylpropanoyl)phenylalanine [MeSH Supplementary Concept]
- 6-(mercaptomethyl)-5-oxo-1-thia-4-azacyclotridecane-3-carboxylic acid [MeSH Supplementary Concept]
- 7-((2-(acetylthio)-1-oxo-3-methylpropyl)amino)-1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido(2,1-a)(2)benzazepin-4-carboxyacid [MeSH Supplementary Concept]
- ACTH (4-7), Pro-Gly-Pro- [MeSH Supplementary Concept]
- AR58 compound [MeSH Supplementary Concept]
- AR60 compound [MeSH Supplementary Concept]
- BMS 182657 [MeSH Supplementary Concept]
- CGS 24128 [MeSH Supplementary Concept]
- CGS 24592 [MeSH Supplementary Concept]
- CGS 25155 [MeSH Supplementary Concept]
- CGS 25462 [MeSH Supplementary Concept]
- CGS 26303 [MeSH Supplementary Concept]
- CGS 37808 [MeSH Supplementary Concept]
- ER 40133 [MeSH Supplementary Concept]
- MDL 100173 [MeSH Supplementary Concept]
- MDL 100240 [MeSH Supplementary Concept]
- N-(2-(mercaptomethyl)-3-methylbutanoyl)-4-(1H-pyrazol-1-yl)phenylalanine [MeSH Supplementary Concept]
- N-(2-(mercaptomethyl)-3-phenylbutanoyl)-L-alanine [MeSH Supplementary Concept]
- N-(fluoresceinyl)-N'-(1-(6-(3-mercapto-2-benzyl-1-oxopropyl)amino)-1-hexyl)thiocarbamide [MeSH Supplementary Concept]
- N-carboxymethyl-phenylalanylleucine [MeSH Supplementary Concept]
- ONO 9902 [MeSH Supplementary Concept]
- RB 104 [MeSH Supplementary Concept]
- RB25 compound [MeSH Supplementary Concept]
- S 21402-1 [MeSH Supplementary Concept]
- SCH 32615 [MeSH Supplementary Concept]
- SCH 42495 [MeSH Supplementary Concept]
- SCH 47896 [MeSH Supplementary Concept]
- SLV 306 [MeSH Supplementary Concept]
- SQ 28603 [MeSH Supplementary Concept]
- UK 77568 [MeSH Supplementary Concept]
- alatriopril [MeSH Supplementary Concept]
- candoxatril [MeSH Supplementary Concept]
- candoxatrilat [MeSH Supplementary Concept]
- glycopril [MeSH Supplementary Concept]
- mixanpril [MeSH Supplementary Concept]
- racecadotril [MeSH Supplementary Concept]
- retrothiorphan [MeSH Supplementary Concept]
- sacubitril and valsartan sodium hydrate drug combination [MeSH Supplementary Concept]
- sch 34826 [MeSH Supplementary Concept]
- spinorphin [MeSH Supplementary Concept]
Record concept(s)
- neprilysin [MeSH concept]
Related MeSH Supplementary Concept(s)
- KB220Z [MeSH Supplementary Concept]
- MMEL1 protein, human [MeSH Supplementary Concept]
- NEP-2 protein, C elegans [MeSH Supplementary Concept]
- Nep4 protein, Drosophila [MeSH Supplementary Concept]
- endopeptidase 24.11, bombyx [MeSH Supplementary Concept]
- neprilysin 2, Drosophila [MeSH Supplementary Concept]
- neprilysin 2, mouse [MeSH Supplementary Concept]
- neprilysin 2, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CD10 [LOINC component]
- CD10 Ag [LOINC component]
- Lymphocyte antigen CD10 (substance) [SNOMED CT concept]
- lymphocyte antigen cd10 [SNOMED Notion]
- membrane metallo-endopeptidase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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