Alpha-Synuclein

Preferred Label : Alpha-Synuclein;

NCIt synonyms : Non-A4 Component of Amyloid Precursor; NACP; Non-A Beta Component of AD Amyloid; SNCA;

NCIt definition : Alpha-synuclein (140 aa, 14 kDa) is encoded by the human SNCA gene. This protein plays a role in the modulation of presynaptic vesicle transport and release.;

NCIt note : Peptides derived from alpha-synuclein are a major component of amyloid plaques in the brains of patients with Alzheimer's disease and non-amyloid aggregates in other synucleopathic neurodegenerative diseases.;

Details

Origin ID

C90119;

UMLS CUI

C1311196;

OMIM relation
- Synuclein, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- SNCA Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Neuron [NCIt concept]
gene_product_has_chemical_classification
- Synuclein Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alpha-Synuclein Signaling Pathway [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Parkinson's Disease Pathway BioCarta [NCIt concept]
- Parkinson's Disease Pathway KEGG [NCIt concept]
gene_product_malfunction_associated_with_disease
- Alzheimer's Disease [NCIt concept]
- Lewy Body Dementia [NCIt concept]
- Parkinson Disease [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Ligand Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Signal Transduction [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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