" /> Synuclein Family - CISMeF





Preferred Label : Synuclein Family;

NCIt definition : Small, soluble Synuclein Family proteins are a group of highly conserved post-transcriptionally modified Alpha, Beta, and Gamma proteins expressed primarily in neural tissue and often localized near synaptic vesicles. Synucleins may inhibit PLD2 and regulate vesicular transport. In the N-terminal portion, synucleins have a conserved repeated 11-residue amphipathic alpha-helical motif similar to the lipid-binding A2 domain of apolipoproteins. Synucleins also contain several repeated variations of a highly conserved KTKEGV domain, also present in rho family proteins. In brain, synucleins may be phosphorylated by Ca2 calmodulin protein kinase II. Synucleins are overexpressed in breast carcinomas and mutations are associated with neurodegenerative illnesses.;

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31/07/2025


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