Beta-Secretase 1

Preferred Label : Beta-Secretase 1;

NCIt synonyms : Aspartyl Protease 2; Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme; Asp 2; ASP2; EC 3.4.23.46; Memapsin-2; Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme 1; Beta-Site APP Cleaving Enzyme 1; APP Beta-Secretase; Memapsin 2; Transmembrane Aspartic Proteinase Asp2; Membrane-Associated Aspartic Protease 2; Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1; BACE1;

NCIt definition : Beta-secretase 1 (501 aa, 56 kDa) is encoded by the human BACE1 gene. This protein plays a role in the proteolysis of ectodomains of membrane proteins.;

NCIt note : Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by beta-secretase 1. (EntrezGene);

Details

Origin ID

C112895;

UMLS CUI

C1569775;

Automatic exact mappings (from CISMeF team)
- Beta-site amyloid beta a4 precursor protein-cleaving enzyme 1 [OMIM gene]
- beta-secretase 1 [HGNC gene]
OMIM relation
- Beta-site amyloid beta a4 precursor protein-cleaving enzyme 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- BACE1 protein, human [MeSH Supplementary Concept]
- BACE1 protein, human [MeSH concept]
gene_encodes_gene_product
- BACE1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Golgi Apparatus [NCIt concept]
gene_product_has_biochemical_function
- Aspartyl Peptidase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Amyloid Beta-Peptide Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Proteolytic Processing [NCIt concept]

Keyword's position in hierarchy(ies) :

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