Growth Arrest-Specific Protein 2

Preferred Label : Growth Arrest-Specific Protein 2;

NCIt synonyms : Growth-Arrest-Specific Protein 2; GAS-2; Growth-Arrest-Specific Protein-2;

NCIt definition : Growth arrest-specific protein 2 (313 aa, 35 kDa) is encoded by the human GAS2 gene. This protein may be involved in both apoptosis and cytoskeletal rearrangement.;

NCIt note : Growth arrest-specific protein 2 is localized at the actin cytoskeleton, along stress fibers, and at the plasma membrane, and is phosphorylated on serine residues during G0/G1 transition. Hyperphosphorylated GAS2 accumulates at membrane ruffles. In apoptosis, GAS2 is a substrate for caspases; cleaved forms of GAS2 induce actin cytoskeletal rearrangements and cell shape changes.;

Details

Origin ID

C29594;

UMLS CUI

C0389006;

OMIM relation
- Growth arrest-specific 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Apoptosis Regulation Gene [NCIt concept]
- GAS2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_biochemical_function
- Regulatory Protein [NCIt concept]
gene_product_is_element_in_pathway
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Maintenance [NCIt concept]
- Regulation of Cell Shape [NCIt concept]
- Regulation of Cell Size [NCIt concept]

Keyword's position in hierarchy(ies) :

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