Tumor Necrosis Factor Ligand Superfamily Member 12

Preferred Label : Tumor Necrosis Factor Ligand Superfamily Member 12;

NCIt synonyms : TWEAK; APO3 Ligand; TNF-Related Weak Inducer of Apoptosis; APO3/DR3 Ligand; TNFSF12; TNF Superfamily Member 12;

NCIt definition : Tumor necrosis factor ligand superfamily member 12 (249 aa, 27 kDa) is encoded by the human TNFSF12 gene. This protein plays a role in the positive regulation of angiogenesis.;

NCIt note : A soluble form of tumor necrosis factor ligand superfamily member 12 is derived from the membrane form by proteolytic processing. (UniProt);

Details

Origin ID

C117068;

UMLS CUI

C0669351;

Automatic exact mappings (from CISMeF team)
- Cytokine TWEAK [MeSH Descriptor]
- TNF superfamily member 12 [ORDO Gene]
- TNF superfamily member 12 [HGNC gene]
- Tumor necrosis factor ligand superfamily, member 12 [OMIM gene]
OMIM relation
- Tumor necrosis factor ligand superfamily, member 12 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TNFSF12 protein, human [MeSH Supplementary Concept]
- TNFSF12 protein, human [MeSH concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- TNFSF12 Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Angiogenesis Promoter [NCIt concept]
- Apoptosis Regulator [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Positive Regulation of Angiogenesis [NCIt concept]
- Signal Transduction Induction [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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